Cytomegalovirus (CMV) pneumonia is an infection of the lungs that can occur in people who have a suppressed immune system.
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CMV pneumonia is caused by a member of a group of herpes-type viruses. Infection with CMV is very common. Most people are exposed to CMV in their lifetime, but typically only those with weakened immune systems become ill from CMV infection.
Serious CMV infections can occur in people with weakened immune systems as a result of:
Chemotherapy or other treatments that suppress the immune system
Organ transplant (especially lung transplant)
In people who have had organ and bone marrow transplants, the risk for infection is greatest 5 to 13 weeks after the transplant.
In otherwise healthy people, CMV usually produces no symptoms, or it produces a temporary mononucleosis-type illness. However, those with a weakened immune system can develop serious symptoms. Symptoms may include:
The goal of treatment is to use antiviral drugs to stop the virus from copying itself in the body. Some people with CMV pneumonia need IV (intravenous) medicines. Some people may need oxygen therapy and breathing support with a ventilator to maintain oxygen until the infection is brought under control.
Antiviral drugs stop the virus from copying itself, but do not destroy it. The CMV suppresses the immune system, and may increase your risk for other infections.
Low oxygen level in the blood of people with CMV pneumonia often predicts death, especially in those who need to be placed on a breathing machine.
Complications of CMV infection in people with HIV/AIDS include spread of disease to other parts of the body, such as the esophagus, intestine, or eye.
Complications of CMV pneumonia include:
Kidney impairment (from drugs used to treat the condition)
Britt WJ. Cytomegalovirus. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 137.
Crothers K, Morris A, Huang L. Pulmonary complications of HIV infection. In: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 90.
Singh N, Haidar G, Limay AP. Infections in solid-organ transplant recipients. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennetts Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 308.
Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA.Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.