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Leukemia
     
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Leukemia

 

Leukemia is a type of blood cancer that begins in the bone marrow. Bone marrow is the soft tissue in the center of the bones, where blood cells are produced.

The term leukemia means white blood. White blood cells (leukocytes) are used by the body to fight infections and other foreign substances. Leukocytes are made in the bone marrow.

Leukemia leads to an uncontrolled increase in the number of white blood cells.

The cancerous cells prevent healthy red cells, platelets, and mature white cells (leukocytes) from being made. Life-threatening symptoms can then develop as normal blood cells decline.

The cancer cells can spread to the bloodstream and lymph nodes. They can also travel to the brain and spinal cord (the central nervous system) and other parts of the body.

Leukemia can affect children and adults.

Leukemias are divided into two major types:

  • Acute (which progresses quickly)
  • Chronic (which progresses more slowly)

The main types of leukemia are:

  • Acute lymphocytic leukemia (ALL)
  • Acute myelogenous leukemia (AML)
  • Chronic lymphocytic leukemia (CLL)
  • Chronic myelogenous leukemia (CML)

 

References

Appelbaum FR. Acute leukemias in adults. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 95.

Hunger SP, Teachey DT, Grupp S, Aplenc R. Childhood leukemia. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 93.

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  • Bone marrow aspiration

    Bone marrow aspiration

    illustration

  • Acute lymphocytic leukemia - photomicrograph

    Acute lymphocytic leukemia - photomicrograph

    illustration

  • Auer rods

    Auer rods

    illustration

  • Chronic lymphocytic leukemia - microscopic view

    Chronic lymphocytic leukemia - microscopic view

    illustration

  • Chronic myelocytic leukemia - microscopic view

    Chronic myelocytic leukemia - microscopic view

    illustration

  • Chronic myelocytic leukemia

    Chronic myelocytic leukemia

    illustration

  • Chronic myelocytic leukemia

    Chronic myelocytic leukemia

    illustration

    • Bone marrow aspiration

      Bone marrow aspiration

      illustration

    • Acute lymphocytic leukemia - photomicrograph

      Acute lymphocytic leukemia - photomicrograph

      illustration

    • Auer rods

      Auer rods

      illustration

    • Chronic lymphocytic leukemia - microscopic view

      Chronic lymphocytic leukemia - microscopic view

      illustration

    • Chronic myelocytic leukemia - microscopic view

      Chronic myelocytic leukemia - microscopic view

      illustration

    • Chronic myelocytic leukemia

      Chronic myelocytic leukemia

      illustration

    • Chronic myelocytic leukemia

      Chronic myelocytic leukemia

      illustration

    A Closer Look

     

    Talking to your MD

     

      Tests for Leukemia

       
       

      Review Date: 2/6/2020

      Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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