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Choroidal dystrophies
     
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Choroidal dystrophies

Choroideremia; Gyrate atrophy; Central areolar choroidal dystrophy

 

Choroidal dystrophies are eye disorders that involve a layer of blood vessels called the choroid. These vessels are between the sclera (the white of the eye) and retina (the inner layer at the back of the eye).

In most cases, a choroidal dystrophy is due to an abnormal gene, which is passed down through families. It most often affects males, starting in childhood.

The first symptoms are peripheral vision loss and vision loss at night. An eye doctor who specializes in the retina can diagnose this disorder.

Exams and Tests

 

The following tests may be needed to diagnose the condition:

  • Electroretinography
  • Fluorescein angiography
  • Genetic testing

 

Treatment

 

Clinical trials have been underway to try to slow the disease progression by injecting a form of the missing genetic material under the retina.

 

 

References

Fleckenstein M, Schmitz-Valckenberg S, Holz FG. Autofluorescence imaging. In: Sadda SVR, Sarraf D, Freund B, et al, eds. Ryan's Retina. 7th ed. Philadelphia, PA: Elsevier; 2023:chap 5.

Freund KB, Sarraf D, Mieler WF, Yannuzzi LA. Hereditary chorioretinal dystrophies. In: Freund KB, Sarraf D, Mieler WF, Yannuzzi LA, eds. Retinal Atlas, The. 2nd ed. Philadelphia, PA: Elsevier; 2017:chap 2.

Rahmani S, Schmitt M, Stepien KE. Inherited retinal diseases. In: Yanoff M, Duker JS, eds. Ophthalmology. 6th ed. Philadelphia, PA: Elsevier; 2023:chap 6.13.

Yanoff M, Sassani JW. Uvea. In: Yanoff M, Sassani JW, eds. Ocular Pathology. 9th ed. Philadelphia, PA: Elsevier; 2025:chap 9.

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  • External and internal eye anatomy

    External and internal eye anatomy

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    • External and internal eye anatomy

      External and internal eye anatomy

      illustration

    Tests for Choroidal dystrophies

     
       

      Review Date: 10/20/2025

      Reviewed By: Franklin W. Lusby, MD, Ophthalmologist, Lusby Vision Institute, La Jolla, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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