Health Library

Lerodalcibep-liga (By injection)

Lerodalcibep-liga (ler-oh-DAL-si-bep - liga)

Reduces LDL cholesterol in patients with high cholesterol in the blood.

Brand Name(s):

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. It is usually given in the stomach, thighs, or back of the upper arms.
• A nurse or other health provider will give you this medicine.
• You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
• You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not inject on skin areas that are bruised, hard, red, or tender or have scars or stretch marks. Do not inject with other injectable medicines at the same site. Do not inject through clothing.
• Prefilled syringe:
  • Wash your hands before and after using this medicine.
  • Allow the medicine to warm to room temperature for at least 30 minutes before using it. Keep the prefilled syringe in the carton to protect from light. Do not warm it in any other way (including microwave). Do not shake it.
  • Gently slide the plastic tray into the palm of your hand and peel off the paper seal with your other hand. Turn the plastic tray over and gently press the middle of the tray's back to release the prefilled syringe. Do not pick up or pull the prefilled syringe by the plunger rod or gray needle cap.
  • Do not remove the gray needle cap until you are ready to inject it. Always hold the syringe by the barrel.
  • Check the liquid in the prefilled syringe. It should be clear to brownish-yellow or amber. Do not use if it is cloudy or has particles in it. Do not use it if the seals are broken or if it has been dropped or damaged.
  • Remove the needle cap. Do not twist the needle cap. Do not touch the plunger rod. Do not remove any air bubbles. Do not recap the syringe.
  • Gently pinch a fold of the skin with one hand. Use a quick and dart-like motion to insert the needle into the skin at a 45 to 90-degree angle. Slowly push the plunger rod all the way down until it is empty.
• Missed dose: Inject a dose as soon as you remember, as long as it is less than 7 days of the missed dose. If it is more than 7 days from your missed dose, inject the dose and start a new monthly schedule using this date.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• If you store this medicine at home, keep it in the refrigerator. Do not freeze. If needed, you may also keep the medicine in the original carton at room temperature for up to 3 months. Throw away any unused medicine after 3 months.
• Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or liver disease.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Fever, chills, cough, runny or stuffy nose, sore throat, body aches
• Rapid weight gain, swelling in your hands, ankles, or feet

If you notice these less serious side effects, talk with your doctor:

• Diarrhea, nausea
• Pain, itching, burning, swelling, or a lump under your skin where the shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 2/4/2026