Health Library

Thioridazine overdose

Thioridazine hydrochloride overdose

Thioridazine is an older, first generation antipsychotic prescription medicine used to treat serious mental and emotional disorders, including schizophrenia. Thioridazine overdose occurs when someone takes more than the normal or recommended amount of this medicine, either by accident or on purpose.

This article is for information only. DO NOT use it to treat or manage an actual overdose. If you or someone you are with overdoses, call the local emergency number (such as 911), or the local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.

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Poisonous Ingredient

Thioridazine

Where Found

Thioridazine hydrochloride is the generic name of this medicine.

Symptoms

Below are symptoms of an overdose of thioridazine in different parts of the body.

BLADDER AND KIDNEYS

• Cannot completely empty the bladder

EYES, EARS, NOSE, AND THROAT

• Blurred vision
• Drooling
• Dry mouth
• Nasal congestion
• Swallowing difficulties
• Ulcers in the mouth, on the tongue, or in the throat
• Vision color changes (brown tinge)
• Yellow eyes

HEART AND BLOOD

• Rapid heartbeat
• Slow heartbeat
• Irregular heartbeat
• High or very low blood pressure

LUNGS

• Difficulty breathing
• Fluid buildup in the lungs
• Breathing may stop in severe cases

MOUTH, STOMACH, AND INTESTINAL TRACT

• Constipation
• Loss of appetite
• Nausea

MUSCLES AND BONES

• Muscle spasms
• Muscle stiffness
• Neck or face stiffness

NERVOUS SYSTEM

• Drowsiness, coma
• Difficulty walking
• Dizziness
• Fever
• Hypothermia (body temperature is lower than normal)
• Seizures
• Tremor
• Weakness, lack of coordination

OTHER

• Menstrual changes
• Blue discoloration of the skin (changing to a purplish color)

Home Care

Get medical help right away. Do not make the person throw up unless poison control or a health care provider tells you to.

Before Calling Emergency

Have this information ready:

• Person's age, weight, and condition
• Name of the medicine and the strength of the medicine, if known
• Time it was swallowed
• Amount swallowed
• If the medicine was prescribed for the person

Poison Control

The local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

You can also get online poison help now at Poisonhelp.org. Just enter the product, poison, or medicine to get expert help.

What to Expect at the Emergency Room

Take the container with you to the hospital, if possible.

Your provider will measure and monitor your vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated. You may receive:

• Activated charcoal
• Blood and urine tests
• Breathing support, including oxygen, or a tube that goes through the mouth into the lungs, and attachment to a breathing machine (ventilator)
  
• CT scan of the brain
• Electrocardiogram (ECG)
• Intravenous fluids (IV, given through a vein)
• Laxative
• Medicine (sodium bicarbonate) to help reverse the effect of the poison
• Tube through the mouth into the stomach to empty the stomach (gastric lavage)
• X-rays (chest and abdomen)

Outlook (Prognosis)

Recovery depends on the amount of damage to the person's body. Survival past 2 days is usually a good sign. The most serious side effects are usually due to damage to the heart. If heart damage can be stabilized, recovery is likely. But if breathing has been depressed for a long period before treatment, brain injury may occur.

References

Aminoff MJ, So YT. Effects of toxins and physical agents on the nervous system. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 86.

Aronson JK. Thioridazine. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:895-899.

Monas J, Skolnik AB. Antipsychotics. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 150.

Review Date: 4/8/2025  

Reviewed By: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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