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Phencyclidine overdose

PCP overdose; Angel dust overdose; Sernyl overdose; Wet overdose

Phencyclidine, or PCP, is an illegal street drug. It can cause hallucinations and severe agitation. This article discusses overdose due to PCP. An overdose is when someone takes more than the normal or recommended amount of something, usually a medicine. An overdose may result in serious, harmful symptoms or death.

This article is for information only. DO NOT use it to treat or manage an actual overdose. If you or someone you are with overdoses, call the local emergency number (such as 911), or the local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.

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Symptoms

Symptoms of PCP overdose include:

• Agitation (overly excited, violent behavior)
• Altered state of consciousness
• Catatonic trance (person does not talk, move, or react)
• Coma
• Convulsions or seizures
• Hallucinations
• High blood pressure
• Side-to-side eye movements (nystagmus)
• Psychosis (loss of contact with reality)
• Uncontrolled movement
• Lack of coordination

People who have used PCP can be dangerous to themselves and others. Do not try to approach an agitated person who you think has used PCP.

Home Care

Seek medical help right away. Do not make the person throw up unless poison control or a health care provider tells you to.

Before Calling Emergency

Have this information ready:

• Person's age, weight, and condition
• Name of product (as well as the ingredients and strength if known)
• Time it was swallowed
• Amount swallowed

Poison Control

The local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

You can also get online poison help now at Poisonhelp.org. Just enter the product, poison, or medicine to get expert help.

What to Expect at the Emergency Room

People being treated for PCP overdose may be sedated and placed in restraints to avoid hurting themselves or medical staff.

Your provider will measure and monitor your vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated.

Additional treatment may include:

• Activated charcoal, if the drug has been taken by mouth
• Blood and urine tests
• Chest x-ray
• CT scan of the brain
• Electrocardiogram (ECG)
• Intravenous fluids (given through a vein)
• Medicines to treat symptoms

Outlook (Prognosis)

The outcome depends on several factors, including:

• The amount of PCP in the body
• The time between taking the drug and receiving treatment

Recovery from the psychotic state may take several weeks. The person should be in a quiet, darkened room. Long-term effects may include kidney failure and seizures. Repeated PCP use may cause long-term psychiatric problems.

Related Information

References

Aronson JK. Phencyclidine. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:670-672.

Barrett W, Iwanicki JL. THC and hallucinogens. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 145.

Brust JCM. Effects of drug abuse on the nervous system. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 87.

Review Date: 4/8/2025  

Reviewed By: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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