Butorphanol (By injection)
Treats pain. This medicine is a narcotic.
Butorphanol Tartrate NovaplusThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. You should not receive it if you had an allergic reaction to butorphanol or to benzethonium chloride.
How to Use This Medicine:
- Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into a muscle or vein.
- A nurse or other health provider will give you this medicine.
- Missed dose: Call your doctor or pharmacist for instructions.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines can affect how butorphanol works. Tell your doctor if you are using any of the following:
- Erythromycin, mirtazapine, theophylline, tramadol, trazodone
- Medicine to treat depression (including MAO inhibitor)
- Phenothiazine medicine
- Do not drink alcohol while you are using this medicine.
- Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are also using buprenorphine, nalbuphine, pentazocine, or a muscle relaxer.
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, high blood pressure, lung or breathing problems (including COPD, apnea), adrenal problems, or a history of brain tumor, head injury, alcohol or drug abuse.
- This medicine may cause the following problems:
- High risk of overdose, which can lead to death
- Respiratory depression (serious breathing problem that can be life-threatening)
- Serotonin syndrome, when used with certain medicines
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Blue lips, fingernails, or skin
- Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures
- Severe confusion, lightheadedness, dizziness, or fainting
- Severe constipation, stomach pain, or vomiting
- Trouble breathing, slow breathing
If you notice these less serious side effects, talk with your doctor:
- Mild constipation
- Pain, itching, burning, swelling, or a lump under your skin where the shot was given
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 3/29/2022