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Heroin overdose

Heroin overdose

Acetomorphine overdose; Diacetylmorphine overdose; Opiate overdose; Opioid overdose


Heroin is a pain-killer derived from morphine. It is very addictive and known for causing significant withdrawal symptoms. It has been illegal in the United States since 1924. It is in the class of drugs known as opioids.

This article discusses heroin overdose. An overdose occurs when someone takes too much of a substance, usually a drug. This can happen by accident or on purpose. A heroin overdose may cause serious, harmful symptoms, or even death.

About heroin overdose:

Heroin overdoses in the United States rose sharply from 2006 to 2015, but since 2016 the number of deaths has trended down. There were 14,019 heroin-related deaths were reported in 2019, with about 10,000 deaths from a combination of heroin and another drug, and about 4,000 deaths from heroin alone. In the United States heroin is sold illegally, so there is no control over the quality or strength of the drug. Also, it is sometimes mixed with other poisonous or dangerous substances, such as fentanyl.

Most people who died from an overdose in the United States from 1999 to 2019 were aged 35 to 54. Many people who use heroin also abuse prescription pain medicines and other drugs. They may also abuse alcohol. These combinations of substances can be very dangerous.

Addiction to prescription opioid painkillers can lead to heroin use. This is because the street price of heroin is often cheaper than that of prescription opioids.

This article is for information only. DO NOT use it to treat or manage an actual overdose. If you or someone you are with has an exposure, call your local emergency number (such as 911), or your local poison center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.

Poisonous Ingredient


Heroin is poisonous. Sometimes, the substances heroin is mixed with are also poisonous.


Where Found


Heroin is made from morphine. Morphine is a strong drug that is found in the seedpods of opium poppy plants. These plants are grown around the world. Pain medicines that contain morphine are called opioids. Opioid is a term derived from opium, which was the Greek word for the juice of the poppy plant. There is no legal medical use for heroin in the United States.

Heroin is also known as diamorphine or diacetylmorphine. Street names for heroin include:

  • Junk
  • Smack
  • H
  • Horse
  • Dope
  • Brown sugar
  • White horse
  • China white
  • Skag




People use heroin to get high because of its effects of short-lived euphoria and blissful apathy. But if they overdose on it, they get extremely sleepy and may become unconsciousness and stop breathing. Most deaths from heroin are due to not breathing.

Below are symptoms of a heroin overdose in different parts of the body.


  • No breathing
  • Shallow breathing
  • Slow and difficult breathing


  • Dry mouth
  • Extremely small pupils, sometimes as small as the head of a pin (pinpoint pupils)
  • Discolored tongue


  • Low blood pressure
  • Weak pulse


  • Bluish-colored nails and lips


  • Constipation
  • Spasms of the stomach and intestines


  • Coma (lack of responsiveness)
  • Delirium (confusion)
  • Disorientation
  • Drowsiness
  • Uncontrolled muscle movements


Home Care


Seek medical help right away. Do NOT make the person throw up unless poison control or a health care provider tells you to do so.

In 2014, the U.S. Food and Drug Administration (FDA) approved the use of a medicine called naloxone (brand name Narcan) to reverse the effects of a heroin overdose. This type of medicine is called an antidote. Naloxone is injected under the skin or into a muscle, using an automatic injector. It can be used by emergency medical responders, police, family members, caregivers, and others. It can save lives until medical care is available.


Before Calling Emergency


Have this information ready:

  • The person's age, weight, and condition
  • How much heroin they took, if known
  • When they took it


Poison Control


Your local poison center can be reached directly by calling the national, toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline number will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.


What to Expect at the Emergency Room


The provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated. The person may receive:

  • Blood and urine tests
  • Breathing support, including oxygen tube through the mouth into the throat, and breathing machine
  • Chest x-ray
  • CT scan (advanced imaging) of the brain if head injury is suspected
  • ECG (electrocardiogram, or heart tracing)
  • Intravenous fluids (IV, through a vein)
  • Medicines to treat symptoms, such as naloxone (see "Home Care" section above), to counteract the effects of the heroin
  • Multiple doses or continuous IV administration of naloxone. This may be needed because naloxone's effects is short-lived and the depressive effects of the heroin are long-lasting.


Outlook (Prognosis)


If an antidote can be given, recovery from an acute overdose occurs within 24 to 48 hours. Heroin is often mixed with substances called adulterants. These can cause other symptoms and organ damage. A hospital stay may be necessary.

If the person's breathing has been affected for a long time, they may breathe fluids into their lungs. This can lead to pneumonia and other lung complications.

Individuals who become unconscious for longer periods of time and lie on hard surfaces may develop crush injuries to the skin and underlying tissue. This may lead to skin ulcers, infection, and deep scarring.

Injecting any drug through a needle can cause serious infections. These include abscesses of the brain, lungs, and kidneys, and heart valve infection.

Because heroin is commonly injected into a vein, a heroin user may develop problems related to sharing needles with other users. Sharing needles can lead to hepatitis, HIV infection, and AIDS.




Centers for Disease Control and Prevention website. Opioids. Updated March 18, 2021. Accessed January 27, 2022.

Hedegaard H, Miniño AM, Warner M. Drug overdose death in the United States, 1999-2019. NCHS Data Brief. 2020 Dec;(394):1-8. PMID: 33395384

Levine DP, Brown P. Infections in injection drug users. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 312.

National Institute on Drug Abuse website. Heroin DrugFacts. Updated June 2021. Accessed January 27, 2022.

National Institute on Drug Abuse website. Overdose death rates. Updated January 20, 2022. Accessed January 27, 2022.

Nikolaides JK, Thompson TM. Opioids. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 156.

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              Review Date: 7/20/2021

              Reviewed By: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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