COVID-19 (Coronavirus) Information
Your health and safety are our top priorities. Learn more about our COVID-19 evaluation and testing and our commitment to providing great care while maintaining the safest environment possible.
CFS; Fatigue - chronic; Immune dysfunction syndrome; Myalgic encephalomyelitis (ME); Myalgic encephalopathy chronic fatigue syndrome (ME-CFS); Systemic exertion intolerance disease (SEID)
Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a long-term illness that affects many body systems. People with this illness are not able to do their usual activities. Sometimes, they may be confined to bed. The condition can also be called systemic exertional intolerance disease (SEID).
One common symptom is severe fatigue. It does not get better with rest and is not directly caused by other medical problems. Other symptoms can include problems with thinking and concentrating, pain, and dizziness.
The exact cause of ME/CFS is unknown. It may have more than one cause. For example, two or more possible causes may work together to trigger the illness.
Researchers are looking into these possible causes:
Genetics or environmental factors may also play a role in the development of ME/CFS:
There are three main, or "core," symptoms in people with ME/CFS:
People with ME/CFS have persistent and profound fatigue and are unable to do activities they were able to do before the illness. This extreme fatigue is:
ME/CFS symptoms can become worse after physical or mental activity. This is called post-exertional malaise (PEM), also known as a crash, relapse, or collapse.
Sleep issues may include problems falling or staying asleep. A full-night's rest does not relieve fatigue and other symptoms.
People with ME/CFS also often experience at least one of the two following symptoms:
Other common symptoms include:
The Centers for Disease Control (CDC) describes ME/CFS as a distinct disorder with specific symptoms and physical signs. Diagnosis is based on ruling out other possible causes.
Your health care provider will try to rule out other possible causes of fatigue, including:
A diagnosis of ME/CFS must include:
There are no specific tests to confirm the diagnosis of ME/CFS. However, there have been reports of people with ME/CFS having abnormal results on the following tests:
There is currently no cure for ME/CFS. The goal of treatment is to relieve symptoms.
Treatment includes a combination of the following:
Some drugs can cause reactions or side effects that are worse than the original symptoms of the disease.
People with ME/CFS are encouraged to maintain an active social life. Mild physical exercise may also be helpful. Your health care team will help you figure out how much activity you can do, and how to slowly increase your activity. Tips include:
Relaxation and stress-reduction techniques can help manage chronic (long-term) pain and fatigue. They are not used as the primary treatment for ME/CFS. Relaxation techniques include:
It also may be helpful to work with a therapist to help you deal with your feelings and the impact of the illness on your life.
Newer medicine approaches are being researched.
Some people may benefit from taking part in an ME/CFS support group.
The long-term outlook for people with ME/CFS varies. It is hard to predict when symptoms first start. Some people completely recover after 6 months to a year.
About 1 in 4 people with ME/CFS are so severely disabled that they can't get out of bed or leave their home. Symptoms can come and go in cycles, and even when people feel better, they may experience a relapse triggered by exertion or an unknown cause.
Some people never feel like they did before they developed ME/CFS. Studies suggest that you are more likely to get better if you receive extensive rehabilitation.
Complications may include:
Call your provider if you have severe fatigue, with or without other symptoms of this disorder. Other more serious disorders can cause similar symptoms and should be ruled out.
Centers for Disease Control and Prevention website. Myalgic encephalomyelitis/chronic fatigue syndrome: treatment. www.cdc.gov/me-cfs/treatment/indexl. Updated November 19, 2019. Accessed July 17, 2020.
Clauw DJ. Fibromyalgia, chronic fatigue syndrome, and myofascial pain. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 258.
Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Board on the Health of Select Populations; Institute of Medicine. Beyond myalgic encephalomyelitis/chronic fatigue syndrome: redefining an illness. Washington, DC: National Academies Press; 2015. PMID: 25695122 pubmed.ncbi.nlm.nih.gov/25695122/.
Ebenbichler GR. Chronic fatigue syndrome. In: Frontera, WR, Silver JK, Rizzo TD, eds. Essentials of Physical Medicine and Rehabilitation. 4th ed. Philadelphia, PA: Elsevier; 2019:chap 126.
Engleberg NC. Chronic fatigue syndrome (systemic exertion intolerance disease). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 130.
Smith MEB, Haney E, McDonagh M, et al. Treatment of myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review for a National Institutes of Health Pathways to Prevention Workshop. Ann Intern Med. 2015;162(12):841-850. PMID: 26075755 pubmed.ncbi.nlm.nih.gov/26075755/.
van der Meer JWM, Bleijenberg G. Chronic fatigue syndrome. In: Cohen J, Powderly WG, Opal SM, eds. Infectious Diseases. 4th ed. Philadelphia, PA: Elsevier; 2017:chap 70.BACK TO TOP
Review Date: 5/31/2020
Reviewed By: Diane M. Horowitz, MD, Rheumatology and Internal Medicine, Northwell Health, Great Neck, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2020 A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.