Lima Memorial Health System Logo
Approximate ER WAIT TIME
10

Health Library

Vulvar cancer
Site Map

Vulvar cancer

Cancer - vulva; Cancer - perineum; Cancer - vulvar; Genital warts - vulvar cancer; HPV - vulvar cancer

Vulvar cancer is cancer that starts in the vulva. Vulvar cancer most often affects the labia, the folds of skin outside the vagina. In some cases, vulvar cancer starts on the clitoris or in glands on the sides of the vaginal opening.

Images

Female perineal anatomy

I Would Like to Learn About:

Causes

Most vulvar cancers begin in skin cells called squamous cells. Other types of cancers found on the vulva are:

  • Adenocarcinoma
  • Basal cell carcinoma
  • Melanoma
  • Sarcoma

Vulvar cancer is rare. Risk factors include:

  • Human papilloma virus (HPV, or genital warts) infection in women under age 50
  • Chronic skin changes, such as lichen sclerosis or squamous hyperplasia in women over age 50
  • History of cervical cancer or vaginal cancer
  • Smoking

Women with a condition called vulvar intraepithelial neoplasia (VIN) may develop into a vulvar cancer that spreads. Most cases of VIN, though, never lead to cancer.

Other possible risk factors may include:

  • History of abnormal Pap smears
  • Having many sexual partners
  • Having first sexual intercourse at 16 or younger

Symptoms

Women with this condition will often have itching around the vagina for years. They may have used different skin creams. They may also have bleeding or discharge outside their periods.

Other skin changes that may occur around the vulva:

  • Mole or freckle, which may be pink, red, white, or gray
  • Skin thickening or lump
  • Skin sore (ulcer) especially if non healing

Other symptoms:

Some women with vulvar cancer have no symptoms.

Exams and Tests

The following tests are used to diagnose vulvar cancer:

Treatment

Treatment involves surgery to remove the cancer cells. If the tumor is large (more than 2 cm) or has grown into the skin, the lymph nodes in the groin area may also be removed.

Radiation, with or without chemotherapy, may be used to treat:

  • Advanced tumors that cannot be treated with surgery
  • Vulvar cancer that comes back
  • Women who are not medically able to undergo surgery

Support Groups

You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.

Outlook (Prognosis)

Most women with vulvar cancer who are diagnosed and treated at an early stage do well. But a woman's outcome depends on:

  • The size of the tumor
  • The type of vulvar cancer
  • Whether the cancer has spread

The cancer commonly comes back at or near the site of the original tumor.

Possible Complications

Complications may include:

  • Spread of the cancer to other areas of the body
  • Side effects of radiation, surgery, or chemotherapy

When to Contact a Medical Professional

Call your health care provider if you have any of these symptoms for more than 2 weeks:

  • Local irritation
  • Skin color change
  • Sore on the vulva

Prevention

Practicing safer sex may decrease your risk for vulvar cancer. This includes using condoms to protect against sexually transmitted infections (STIs).

A vaccine is available to protect against certain forms of HPV infection. The vaccine is approved to prevent cervical cancer and genital warts. It may help prevent other cancers linked to HPV, such as vulvar cancer. The vaccine is given to young girls before they become sexually active, and to adolescents and women up to age 45.

Routine pelvic exams can help detect vulvar cancer at an earlier stage. Earlier diagnosis improves your chances that treatment will be successful.

Related Information

Squamous cell skin cancer
Genital warts
Cancer
Cervical cancer
Vaginal cancer
Diabetes
Overweight
High blood pressure in adults - hypertension

References

Frumovitz M. Neoplastic diseases of the vulva and vagina. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Comprehensive Gynecology. 7th ed. Philadelphia, PA: Elsevier; 2017:chap 30.

Jhingran A, Russell AH, Seiden MV, et al. Cancers of the cervix, vulva, and vagina. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 84.

National Comprehensive Cancer Network website. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Vulvar cancer (squamous cell cardinoma) Version 1.2022 – October 7, 2021 www.nccn.org/professionals/physician_gls/pdf/vulvar.pdf.

National Cancer Institute website. Vulvar cancer treatment (PDQ) - health professional version. www.cancer.gov/types/vulvar/hp/vulvar-treatment-pdq. Updated January 25, 2022. Accessed April 21, 2022.

BACK TO TOP

Review Date: 1/1/2022  

Reviewed By: Howard Goodman, MD, Gynecologic Oncology, Florida Cancer Specialists & Research Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

ADAM Quality Logo

A.D.A.M., Inc. is accredited by URAC, for Health Content Provider (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics. This site complies with the HONcode standard for trustworthy health information: verify here.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2022 A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

adam.com

A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.