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Phlegmasia cerulea dolens

Deep vein thrombosis - Phlegmasia cerulea dolens; DVT - Phlegmasia cerulea dolens; Phlegmasia alba dolens

Phlegmasia cerulea dolens is an uncommon, severe form of deep venous thrombosis (blood clots in a vein). It most often occurs in the upper leg.

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Causes

Phlegmasia cerulea dolens is preceded by blood clots in a vein, usually a deep vein of the leg.

Symptoms

Severe pain, rapid swelling, and bluish skin coloring affect the area below the blocked vein.

Possible Complications

Continued clotting can lead to increased swelling. The swelling can interfere with arterial blood flow. This complication is called phlegmasia alba dolens. It causes the skin to turn white. Phlegmasia alba dolens may lead to tissue death (gangrene) and the need for amputation.

When to Contact a Medical Professional

Seek medical help right away if an arm or leg is severely swollen, blue, or painful.

Related Information

References

Chan NC, Weitz JI. Venous thromboembolism. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 140.

Johanning JM, Thompson JR, Lynch TG. Clinical evaluation of the venous and lymphatic systems. In: Sidawy AN, Perler BA, eds. Rutherford's Vascular Surgery and Endovascular Therapy, 2-Volume Set. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 20.

Kabrhel C. Pulmonary embolism and deep vein thrombosis. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 74.

Review Date: 1/29/2026  

Reviewed By: Warren Brenner, MD, Oncologist, Lynn Cancer Institute, Boca Raton, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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