Eculizumab (By injection)
Treats paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and generalized myasthenia gravis (gMG).
SolirisThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. You should not receive it if you had an allergic reaction to eculizumab or if you have a meningococcal infection. You should not receive this medicine if you have not been vaccinated against meningitis infection unless your doctor decides that urgent treatment with eculizumab is needed.
How to Use This Medicine:
- Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. The medicine must be injected slowly, so your IV will need to stay in place for at least 35 minutes.
- A nurse or other health provider will give you this medicine.
- This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
- Missed dose: Call your doctor or pharmacist for instructions.
Drugs and Foods to Avoid:
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant or breastfeeding, or if you have blood or bone marrow problems (including neutropenia), a weak immune system, or any kind of infection.
- This medicine can increase your risk of serious infections, including meningococcal infection. You will need to be vaccinated against meningococcal infection at least 2 weeks before you start treatment with this medicine. You will also be given a patient safety card that lists the symptoms of infection and what to do if you have them. Carry the card with you at all times. Show the card to any doctor who treats you.
- This medicine can also cause an infusion reaction that can be life-threatening.
- For patients with PNH: When you stop receiving this medicine, you could develop hemolysis (breakdown of red blood cells). Your doctor will monitor you for at least 8 weeks.
- For patients with aHUS: When you stop receiving this medicine, you could develop a type of blood clot called thrombotic microangiopathy. Your doctor will monitor you for at least 12 weeks to watch for this.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Change in how much or how often you urinate
- Confusion, sensitivity to light, severe headache, nausea, vomiting, stiff neck
- Fast or uneven heartbeat
- Fever, chills, cough, sore throat, body aches
- Rapid weight gain, swelling in your hands, ankles, or feet
- Unusual bleeding, bruising, weakness
If you notice these less serious side effects, talk with your doctor:
- Back pain
- Diarrhea, stomach pain
- Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
- Runny or stuffy nose
If you notice other side effects that you think are caused by this medicine, tell your doctor
Last Updated: 1/4/2018