A stereotactic biopsy is done to evaluate a lump that cannot be felt on breast examination but is seen on mammogram or ultrasound. It is done using a special type of X-ray instrument that can precisely locate the area of the breast from which the biopsy sample is to be taken. A small incision is then made in the skin of the breast and a needle is guided by the instrument to the exact biopsy site to collect a tissue sample. Stereotactic biopsy may not be appropriate for all types of breast lumps.

An ultrasound biopsy is a test that uses reflected sound waves to produce an image of organs and other structures in the body. It does not use X-rays or other types of possibly harmful radiation.